2013 - PRESENT

  1.  Kheiri S, Kumacheva E, Young EWK, “Computational Modelling and Big Data Analysis of Flow and Drug Transport in Microfluidic Systems: A Spheroid-on-a-Chip Study”, Front. Bioeng. Biotechnol., 9:781556 (2021). 
  2. Prince E, Kheiri S, Wang Y, Xu F, Cruikshank J, Topolskaia V, Tao H, Young EWK, McGuigan A, Cescon D, Kumacheva E, “Microfluidic arrays of breast tumor spheroids for drug screening and personalized cancer therapies”, Advanced Healthcare Materials, accepted (2021).
  3. Walji N, Kheiri S, Young EWK, “Angiogenic sprouting dynamics mediated by endothelial-fibroblast interactions in microfluidic systems”, Advanced Biology, accepted (2021).
  4. Park S, Young EWK, “E-FLOAT: Extractable Floating Liquid gel-based Organ-on-a-Chip for Airway Tissue Modelling under Airflow”, Advanced Materials Technologies, 2100828, 1-12 (2021).
  5. Mohan M, Young EWK, “TANDEM: Biomicrofluidic Systems with Transverse and Normal Diffusional Environments for Multidirectional Signalling”, Lab Chip, accepted (2021). (*Cover article).
  6. Chen ZK, Kheiri S, Gevorkian A, Young EWK, Andre V, Deisenroth T, Kumacheva E, “Microfluidic arrays of dermal spheroids: a screening platform for active ingredients of skincare products”, Lab Chip, 21: 3952-3962(2021).
  7. Ma J, Tran G, Wan AMD, Young EWK, Kumacheva E, Iscove NN, Zandstra PW, “Microdroplet-based one-step RT-PCR for Ultrahigh Throughput Single-Cell Multiplex Gene Expression Analysis and Rare Cell Detection”, Scientific Reports, 11: 6777 (2021). 
  8. Gevorkian A, Morozova, SM, Kheiri S, Khuu N, Chen H, Young EWK, Yan N, Kumacheva E, “Actuation of 3D-printed Nanocolloidal Hydrogel with Structural Anisotropy”, Advanced Functional Materials, Art. No. 2010743 (2021). 
  9. Ying B, Park S, Chen L, Dong X, Young EWK, Liu XY, “NanoPADs and NanoFACEs: an optically transparent nanopaper-based device for biomedical applications”, Lab Chip, 20: 3322-3333 (2020). 
  10. Mastikhina O, Moon B-U, Williams K, Hatkar R, Gustafson D, Sun X, Koo M, Lam AYL, Sun Y, Fish JE, Young EWK, Nunes SS, “Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing”, Biomaterials, 233, 119741 (2020).
  11. Wong JF, Mohan MD, Young EWK, Simmons CA, “Integrated electrochemical measurement of endothelial permeability in a 3D hydrogel-based microfluidic vascular model”, Biosensors and Bioelectronics, 147, 111757 (2020).
  12. Devadas D, Moore TA, Walji N, Young EWK, “A microfluidic mammary gland coculture model using parallel 3D lumens for studying epithelial-endothelial migration in breast cancer”, Biomicrofluidics, 13, 064122 (2019).
  13. Chowdury MA, Heileman KL, Moore TA, Young EWK, “Biomicrofluidic Systems for Hematologic Cancer Research and Clinical Applications”, SLAS Technology, 24(5): 457-476 (2019).
  14. Mei X, Middleton K, Wan Q, Shim D, Xu L, Ma Y-H, Devadas D, Walji N, Young EWK, You L, “Microfluidic Platform for studying osteocyte mechanoregulation of breast cancer metastasis”, Integrative Biology, 11(4): 119-129 (2019).
  15. Kuzmic N, Moore TA, Devadas D, Young EWK, “Modelling of endothelial cell migration and angiogenesis in microfluidic cell culture systems”, Biomechanics and Modeling in Mechanobiology, 18(3): 717-731 (2019).
  16. Riordon J, Sovilj D, Sanner S, Sinton DA, Young EWK, “Deep learning with Microfluidics for Biotechnology”, Trends in Biotechnology, 37(3): 310-324 (2018).
  17. Humayun M, Chow CW, Young EWK, “Microfluidic Lung Airway-on-a-Chip with Arrayable Suspended Gels for Studying Epithelial and Smooth Muscle Cell Interactions”, Lab on a Chip, 18: 1298-1309 (2018). (*Highlighted in the Lab on a Chip Emerging Investigators Series; included in themed collection “Organ-, body- and disease-on-a-chip systems”).
  18. Wong JF, Young EWK, Simmons CA, “Computational Analysis of Integrated Biosensing and Shear Flow in a Microfluidic Vascular Model”, AIP Advances, 7(11): 115116 (2017).
  19. Moore TA, Brodersen P, Young EWK, “Multiple Myeloma Cell Drug Responses Differ in Thermoplastic vs. PDMS Microfluidic Devices”, Analytical Chemistry, 89(21): 11391-11398 (2017).
  20. Moore TA, Li A, Young EWK, “Integrating Population Heterogeneity Indices with Microfluidic Cell-Based Assays”, SLAS Discovery, DOI: 10.1177/2472555217738533 (2017).
  21. Wan AMD*, Devadas D*, Young EWK, “Recycled Polymethylmethacrylate (PMMA) Microfluidic Devices”, Sensors & Actuator: Chemical B, 253: 738-744 (2017).
  22. Wan AMD, Moore TA, Young EWK, “Solvent Bonding for Fabrication of PMMA and COP Microfluidic Devices”, J. Visualized Experiments, 119: e55175, DOI:10.3791/55175 (2017).
  23. Moore TA, Young EWK, “Single cell functional analysis of multiple myeloma cell population correlates with diffusion profiles in static microfluidic coculture systems”, Biomicrofluidics, 10: 044105 1-17 (2016). (*Winner of 2016 Biomicrofluidics Best Paper Award).
  24. Konstantinou D, Shirazi A, Sadri A, Young EWK, “Combined hot embossing and milling for medium volume production of thermoplastic microfluidic devices”, Sensors & Actuator B: Chemical, 234: 209-221 (2016).
  25. Young EWK, Moraes C, “Patients are a virtue: advances in microengineered systems for clinical applications”, Integrative Biology, 7: 962-966 (2015). (Research highlight)
  26. Wan AMD, Sadri A, Young EWK, “Liquid phase solvent bonding of plastic microfluidic devices assisted by retention grooves”, Lab on a Chip, 15: 3785-3792 (2015).
  27. Hwang B, Wan J, Wuerzberger-Davis SM, Young EWK, Choi EY, Cingolani G, Weaver B, Miyamoto S, “IPO3 mediated nonclassical nuclear import of NEMO drives DNA damage-dependent NF-kB activation”, J. Biological Chemistry, 290(29): 17967-84 (2015).
  28. Pak C, Callander NS, Young EWK, Titz B, Kim KM, Saha S, Chng K, Asimakopoulos F, Beebe DJ, Miyamoto S, “MicroC3: an ex vivo microfluidic cis-coculture assay to rapidly test chemosensitivity and resistance of patient multiple myeloma cells”, Integrative Biology, 7: 643-654 (2015). (*Cover article)
  29. Guckenberger DJ, de Groot T, Wan AMD, Beebe DJ, Young EWK, “Micromilling: A method for ultra-rapid prototyping of plastic microfluidic devices”, Lab on a Chip, 15: 2364-2378 (2015). (*Cover article)
  30. Theberge AB, Yu J, Young EWK, Ricke WA, Bushman W, Beebe DJ, “Microfluidic multiculture assay to analyze biomolecular signaling in angiogenesis”, Analytical Chemistry, 87(6): 3239-3246 (2015).
  31. Guckenberger DJ, Berthier E*, Young EWK*, Beebe DJ, “Fluorescence-based Assessment of Plasma-induced Hydrophilicity (FAPH) in Microfluidic Devices via Nile Red Adsorption and Depletion”, Analytical Chemistry, 86(15): 7258-7263 (2014).
  32. Young EWK, “Advances in Microfluidic Cell Culture Systems for Studying Angiogenesis ”, Journal of Laboratory Automation, 18(6): 427-436 (2013).
  33. Young EWK, “Cells, tissues, and organs on chips: challenges and opportunities for the cancer tumor microenvironment”, Integrative Biology, 5(9): 1096-1109 (2013). (*Cover article; **Top 5 downloaded articles in 2013, Integrative Biology).
  34. Hong W, Young EWK, Tepp W, Johnson E, Beebe DJ, “A Microscale Neuron and Schwann Cell Coculture Model for Increasing Detection Sensitivity of Botulinum Neurotoxin Type A”, Toxicological Sciences, 134(1): 64-72 (2013).
  35. Warrick JW, Young EWK, Schmuck EG, Saupe KW, Beebe DJ, “High-content adhesion assay to address limited cell samples”, Integrative Biology, 5(4): 720-727 (2013).
  36. Young EWK*, Berthier E*, Beebe DJ, “Assessment of enhanced autofluorescence and impact on cell microscopy for microfabricated thermoplastic devices”, Analytical Chemistry, 85(1): 44-49 (2013).
  37. Bischel LL, Young EWK, Mader BR, Beebe DJ, “Tubeless microfluidic angiogenesis assay with three-dimensional endothelial-lined microvessels”, Biomaterials, 34(5): 1471-1477 (2013). (doi: 10.1016/j.biomaterials.2012.11.005)

PRE - 2013

  1. Sackmann EK, Berthier E, Young EWK, Shelef S, Wernimont SA, Huttenlocher A, Beebe DJ, “Microfluidic kit-on-a-lid: a versatile platform for neutrophil chemotaxis assays” Blood, 120(14): e45-e53 (2012).
  2. Guckenberger DJ, Berthier E*, Young EWK*, Beebe DJ, “Induced hydrophobic recovery of oxygen plasma-treated surfaces”, Lab Chip, 12(13): 2317-2321 (2012).
  3. Berthier E*, Young EWK*, Beebe DJ, “Engineers are from PDMS-land, Biologists are from Polystyrenia”, Lab Chip, 12(7): 1224-1237 (2012). (*Cover article)
  4. Young EWK, Pak C, Kahl BS, Yang DT, Callander NS, Miyamoto S, Beebe DJ, “Microscale functional cytomics for studying hematologic cancers”, Blood, 119(10): e76-e85 (2012).
  5. Young EWK*, Berthier E*, Guckenberger DJ, Sackmann E, Lamers C, Meyvantsson I, Huttenlocher A, Beebe DJ, “Rapid prototyping of arrayed microfluidic systems in polystyrene for cell-based assays”, Analytical Chemistry, 83(4): 1408-1417 (2011).
  6. Su X, Young EWK, Underkofler HAS, Kamp TJ, January CT, and Beebe DJ, “Microfluidic cell culture and its application in high throughput drug screening: cardiotoxicity assay for hERG channels”, Journal of Biomolecular Screening, 16(1): 101-111 (2011).
  7. Yuen A, Laschinger C, Talior I, Lee W, Chan M, Birek J, Young EWK, Sivagurunathan K, Won E, Simmons CA, McCulloch CA, “Methylglyoxal-modified collagen promotes myofibroblast differentiation”, Matrix Biology, 29(6): 537-548 (2010).
  8. Young EWK, Beebe DJ, “Fundamentals of microfluidic cell culture for controlled micro-environments”, Chemical Society Reviews, 39(3): 1036-1048 (2010).
  9. Young EWK, Watson MWL, Srigunapalan S, Wheeler AR, Simmons CA, “Technique for real-time measurements of endothelial permeability in a microfluidic membrane chip using laser-induced fluorescence detection”, Analytical Chemistry, 82(3): 808-816 (2010).
  10. Young EWK, Simmons CA, “Macro- and microscale fluid flow systems for endothelial cell biology”, Lab Chip, 10(2): 143-160 (2010). (*Cover article)
  11. Young EWK, Simmons CA, “ ‘Student lab’-on-a-chip: Integrating low-cost microfluidics into undergraduate teaching labs to study multiphase flow phenomena in small vessels”, Chem. Eng. Ed., 43(3): 232-240 (2009).
  12. Cheung WY*, Young EWK*, Simmons CA, “Techniques for isolating and purifying porcine aortic valve endothelial cells”, Heart Valve Disease, 17(6): 674-681 (2008).
  13. Abdelgawad M, Watson MWL, Young EWK, Mudrik JM, Ungrin MD, Wheeler AR, “Soft lithography: masters on demand”, Lab Chip, 8(8): 1379-1385 (2008).
  14. Spiteri CG, Young EWK, Simmons CA, Kandel RA, Pilliar RM, “Substrate architecture and fluid-induced shear stress during chondrocyte seeding: role of a5b1 integrin”, Biomaterials, 29(16): 2477-2489 (2008).
  15. Li W, Young EWK, Seo M, Nie Z, Garstecki P, Simmons CA, Kumacheva E, “Simultaneous generation of droplets with different dimensions in parallel integrated microfluidic droplet generators”, Soft Matter, 4(2): 258-262 (2008).
  16. Young EWK, Wheeler AR, Simmons CA, “Matrix-dependent adhesion of vascular and valvular endothelial cells in microfluidic channels”, Lab Chip, 7(12): 1759-1766 (2007).
  17. Fiddes LK, Young EWK, Kumacheva E, Wheeler AR, “Flow of microgel capsules through topographically patterned microchannels”, Lab Chip 7(7): 863-867 (2007).
  18. Chong SA, Lee W, Arora PD, Laschinger C, Young EWK, Simmons CA, Manolson M, Sodek J, McCulloch CA, “Methylglyoxal inhibits the binding step of collagen phagocytosis”, Biological Chemistry, 282(11): 8510-8520 (2007).
  19. Young EWK, Martinez DM, Olson JA, Buckley K, Jivan S, Ruth TJ, Sossi V, “The sedimentation of papermaking fibres”, AIChE Journal, 52(8): 2697-2706 (2006).
  20. Young EWK, Li DQ, “Dielectrophoretic force on a sphere near a planar boundary”, Langmuir, 21(25): 12037-12046 (2005).
  21. Young EWK, Olson JA, “Development of a continuous high-efficiency laboratory fibre fractionator”, J. Chem. Eng., 82 (3): 433-441 (2004).